Pioneering Heart Failure Research: Innovation, Translation, and Myocardial Recovery.

The Selzman Lab advances translational science on cardiac remodeling, reverse remodeling, and ischemia-reperfusion injury to recover the failing heart.

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Revolutionizing Heart Health:

Discovering Novel Therapeutic Targets for Myocardial Recovery

The Selzman Lab is an NIH-funded translational science laboratory investigating the molecular and transcriptional mechanisms of cardiac remodeling, myocardial recovery and reverse remodeling, and ischemia-reperfusion injury.

About Selzman Lab

Our Research

The Selzman Lab investigates the molecular and transcriptional mechanisms of cardiac remodeling, myocardial recovery and reverse remodeling, and ischemia-reperfusion injury — from experimental models to translational studies in heart failure.

Transcriptional regulation in cardiac remodeling

Metabolic and molecular mechanisms of myocardial recovery

Cardiac remodeling and reverse remodeling in heart failure

Ischemia-reperfusion injury

Featured Publications

Recent publications highlight groundbreaking findings on the genetic mechanisms of heart disease, novel therapeutic approaches for heart failure, and innovative strategies for improving cardiovascular health outcomes.

CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer

_{— Carley AN et al., Circ Res. 2026;138(2):e327403.}

The Role of Sphingolipids in Myocardial Recovery Mediated by Mechanical Unloading and Circulatory Support

_{— Hamouche R et al., JACC Basic Transl Sci. 2026;11(1):101435.}

Targeting leukocytes, neutrophil extracellular traps and cytokines: A conceptual review to prevent primary graft dysfunction after lung transplantation

_{— Kagawa H et al., Transplant Rev (Orlando). 2026;40(2):100989.}

The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure

_{— Badolia R et al., Circulation. 2020;142(3):259-274.}

Mentorship and Training

Dr. Selzman has a strong commitment to mentoring the next generation of scientists and physician-scientists.

Dr. Selzman leads a translational science laboratory at the Cardiovascular Research and Training Institute (CVRTI) with scientists, trainees, and collaborators. The lab trains its members in cardiothoracic surgical research — from experimental models to translational clinical studies on heart failure and myocardial recovery.

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Faculty

Craig Selzman, MD

Professor and Chief, Division of Cardiothoracic Surgery

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